Several studies attempt to unravel the causes of excitatory/inhibitory imbalance in schizophrenia. The pitfall is the loose control of the exact target cells keeping an excessive level of abstraction. Enrico Patrono argues that implementing microfluidic chips called Brain-on-a-Chip, an innovative in-vitro-silico model for neural circuits allows high temporal and spatial control of molecules and cells in schizophrenia.

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