The nominating institution Weizmann Institute of Science on the breakthrough:
ALS is an incurable and fatal disease. A recent landmark study has identified a bioactive gut microbiome commensal and secreted product (nicotinamide) as disease modifying in ALS-prone mice. Importantly, human patients featured similar microbial and CNS metabolite alterations. This work provides a conceptual paradigm change, and potentially new therapeutic horizons for this fatal disease.
Tags: Bio-Tech, Medicine