Presented by

Philipp Schulte

Nominated by
Technical University Munich

 

FasCiPlex has developed a new more efficient enzyme for an economic conversion of biomass to sugar. Biomass is an abundant feedstock mainly composed of cellulose which in turns is composed of 100% glucose. The sugar can be released by synergistic enzyme activity of cellulases. State of the art since over 60 years are fungal soluble cellulases. So far biomass conversion using fungal cellulases is not cost competitive. Our paradigm is the most effective cellulase in nature – the cellulosome of Clostridium thermocellum, a multi-enzyme complex. The cellulosome is thermophilic (55-70 °C), highly stable and attaches to the substrate for enhanced enzyme activity. Complex formation leads to local increase in enzyme concentration thereby enhancing synergism of the individual enzyme functions resulting in more sugar per enzyme unit. We build artificial recombinant complexes by binding selected enzymes to a core protein. Our FasCiPlex prototype is superior compared to the best available commercial cellulases on an industrial substrate and has the potential of 3.5x improvement. A PCT application was filed in 2011. With FasCiPlex we want to make biomass valorization cost competitive.

More Venture Finalists

All Venture Finalists

Further Activities to have a look at

We use cookies and other technologies to collect data about your use of our site and about your browser, device and location. We process this data to help us understand how the site is used and to personalize our content and the advertising you see on this and other sites we also share this data with advertising, social media and analytics partners for the same purposes. By choosing “Accept All” you agree that we store cookies on your device and process the data for the aforementioned purposes . You may revoke your consent at any time by choosing the respective settings. For more information on the processing of personal data and what specific services we use see our Privacy Policy

Privacy Preference Center

We use cookies and other technologies to collect data about your use of our site and about your browser, device and location. We process this data to help us understand how the site is used and to personalize our content and the advertising you see on this and other sites we also share this data with advertising, social media and analytics partners for the same purposes. By choosing “Accept All” you agree that we store cookies on your device and process the data for the aforementioned purposes . You may revoke your consent at any time by choosing the respective settings. For more information on the processing of personal data and what specific services we use see our Privacy Policy

Necessary Cookies

These cookies are required to provide you with our site and its functions. Since storing these cookies is necessary for the provision of our site and its functions, you cannot disable them. If you block these cookies via you browser settings our site may not function properly.

Analyse Cookies

These cookies enable us to use website analytics in order to improve our site or provide you with personalized content. They may be set by us or by third party providers whose services we have added to our pages.

Marketing Cookies

These cookies enable us to use online marketing and advertising in order to provide you on this or on other sites with personalized advertisement. They may be set by us or by third party providers whose services we have added to our pages.