Presented by
Shigeki Moriguchi

Nominated by
Tohoku University

 

Brain Innovation is developing a novel drug to treat Alzheimer’s disease. Seeking to improve the behavioural and psychological symptoms of dementia, the drug tackles the disease in a different way than the conventional approved medication available on the market. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterised by cognitive deficits and memory loss. In addition, the expression of behavioural and psychological symptoms of dementia, such as depression, aggression, psychosis, is observed in the later stages of AD.  It is well known that AD is associated with both down-regulation of the cholinergic system and aggregation of amyloid-β (Aβ) in the brain. Currently, only symptomatic therapies are approved: three anticholinesterase inhibitors and one N-methyl-D-aspartate receptor (NMDAR) inhibitor. One recent development is a novel therapy using Aβ-aggregation inhibitors, but success has been limited. Brain Innovation reports a novel target of the drug memantine (Memari), ATP-sensitive potassium (KATP) channels, which is potentially relevant to memory improvement. Studies have shown that modulation of KAPT channel activity is a novel target for therapeutics to improve memory impairment and the behavioural and psychological symptoms of dementia.

More Venture Finalists

All Venture Finalists

Further Activities to have a look at

We use cookies and other technologies to collect data about your use of our site and about your browser, device and location. We process this data to help us understand how the site is used and to personalize our content and the advertising you see on this and other sites we also share this data with advertising, social media and analytics partners for the same purposes. By choosing “Accept All” you agree that we store cookies on your device and process the data for the aforementioned purposes . You may revoke your consent at any time by choosing the respective settings. For more information on the processing of personal data and what specific services we use see our Privacy Policy

Privacy Preference Center

We use cookies and other technologies to collect data about your use of our site and about your browser, device and location. We process this data to help us understand how the site is used and to personalize our content and the advertising you see on this and other sites we also share this data with advertising, social media and analytics partners for the same purposes. By choosing “Accept All” you agree that we store cookies on your device and process the data for the aforementioned purposes . You may revoke your consent at any time by choosing the respective settings. For more information on the processing of personal data and what specific services we use see our Privacy Policy

Necessary Cookies

These cookies are required to provide you with our site and its functions. Since storing these cookies is necessary for the provision of our site and its functions, you cannot disable them. If you block these cookies via you browser settings our site may not function properly.

Analyse Cookies

These cookies enable us to use website analytics in order to improve our site or provide you with personalized content. They may be set by us or by third party providers whose services we have added to our pages.

Marketing Cookies

These cookies enable us to use online marketing and advertising in order to provide you on this or on other sites with personalized advertisement. They may be set by us or by third party providers whose services we have added to our pages.