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Craig M. Crews

YALE UNIVERSITY

John C. Malone Professor of Molecular, Cellular, and Developmental Biology, and Professor of Chemistry, of Pharmacology, and of Management at Yale University, New Haven, Connecticut, USA

Craig M. Crews is a pioneer in the field of controlled protein degradation. His early research, which was focused on blocking the cell’s protein degradation machinery, led to an FDA-approved drug used to treat multiple myeloma. More recently, Craig M. Crews conceived and demonstrated proof-of-concept of an entirely new approach to control protein levels in cells: the so-called PROTAC technology (PROTteolysis TArgeting Chimera). PROTACs activate a cell’s quality control system to target disease-causing proteins for degradation, paving the way for entirely new treatment options for various diseases. The first PROTACs are already in clinical trials by the Yale-based company Arvinas, which Craig M. Crews founded a few years ago. They target the androgen and estrogen receptors in patients with metastatic prostate and breast cancer.

Events with Craig M. Crews

Mon | Nov 02, 2020 | 16.00 - 17.00 Europe/Berlin Time

Starting up Science: From Lab to Therapy

We are proud to welcome more than 500 speakers from the global science community on our digital stage from 1 – 10 November 2020. At the intersection of science and society they present and discuss some of the most pressing topics of our time.

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Further Activities to have a look at

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