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Life Sciences Digital Education Advances in Health & Medicine

Organoide des menschlichen Gehirns alias “Mini-Gehirne” als Werkzeuge zur Erforschung von Krankheiten des Nervensystems (DE)

Max-Delbrück-Centrum für Molekulare Medizin | Agnieszka Rybak-Wolf, Anna Löwa, Miriam Wandres, Luiza Bengtsson

In dieser Lehrerfortbildung erleben Sie den neuesten Stand der Wissenschaft und erhalten wertvolle Informationen über aktuelle Trends in der Life-Science-Forschung - dieses Mal geht es um Mini-3D- Zellkulturen des Gehirns.

Die Organoide sind 3D-Kulturen aus Stammzellen, welche die zelluläre Komplexität und Funktionalität menschlicher Organe in vitro abbilden. Unter Verwendung von Organoiden werden Forschern tiefere Einblicke in die entscheidenden zellulären Prozesse bei der Gewebe- und Organbildung sowie in pathologischen Prozessen in vitro ermöglicht. Da das menschliche Gehirn einzigartig ist, und selbst Primatenmodelle die Ausbildung neurologischer Erkrankungen des menschlichen Gehirns nicht genau darstellen, ist die Entwicklung der sogenannten Mini-Gehirne ein entscheidender Durchbruch. In diesem Kurs möchten wir Ihnen die Grundlagen der Mini-Gehirne, ihre Anwendung sowie die Limitierungen vorstellen.

Die Fortbildung 4ndet in der Arbeitsgruppe von Prof. Dr. Nikolaus Rajewsky: Systems Biology of Gene Regulatory Elements statt, als Teil einer Fortbildungsreihe „Labor trifft Lehrer – digital!“

ÖFFENTLICHER WORKSHOP FÜR LEHRENDE AUF ADOBE CONNECT. BITTE ANMELDEN.

Dies ist ein digitales Event. Bitte melden Sie sich für diese Veranstaltung bis zum 9. November hier an.

Der Zugang zur Veranstaltung wird durch den Organisator und nach Anmeldung zur Verfügung gestellt.

Diese Veranstaltung findet auf Deutsch statt.

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Felix Petermann, MDC

Agnieszka Rybak-Wolf

Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)

Head of the Technology Platform Organoids

Dr. Agnieszka Rybak-Wolf heads the MDC’s newly established Organoids Platform. She previously studied the expression and function of regulatory RNAs, such as miRNAs and circular RNAs, during neuronal specification and mammalian brain development. Her current research employs a brain organoid model to study human neurodegenerative diseases, with the goal of elucidating pathogenic mechanisms underlying their development and identifying potential therapeutic targets for disease treatment.

Anna Löwa

Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft, Berliner Institut für Medizinische Systembiologie

Scientist at the Technology Platform Organoids

Dr. Anna Löwa works as a postdoc for the Organoid Platform of the MDC Berlin. Already in her doctoral thesis she was engaged in the development of human 3D tissue cultures for the precise replication of organs in order to use them for the research of diseases. Currently, she concentrates on generating brain organoids. Here the focus is on the investigation of the pathomechanisms of Alzheimer’s disease by using stem cells from patients.

Miriam Wandres

Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft, Berliner Institut für Medizinische Systembiologie

PhD Student in the Research Lab of Prof. Dr. Nikolaus Rajewsky, Systems Biology of Gene Regulatory Elements

Miriam Wandres is doing her doctorate in the laboratory of Nikolaus Rajewsky at the MDC-Berlin. She is currently working with brain organoids: miniature artificial brain-like structures which grow in a petri dish. The aim of her doctoral thesis is to develop therapeutic options for diseases such as Alzheimer’s and glioblastoma.

Tamara Worzewski

Luiza Bengtsson

Max-Delbrück-Centrum für Molekulare Medizin // BesserWissen e.V.

Public Engagement and Knowledge Exchange / CEO BesserWissen e.V.

Dr. Luiza Bengtsson, PhD in Biochemistry in 2002, studied & researched chemistry and humanities in Sweden, Germany and USA. In 2011, she went from life sciences research uncovering communication channels in cells to creating new channels for dialog between science and society. She now organizes science popularization events, trains high school teachers in science and researchers in Open Science and produces art-science and citizen science collaborations as well as the ORION Open Science podcast.

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Organoide des menschlichen Gehirns alias “Mini-Gehirne” als Werkzeuge zur Erforschung von Krankheiten des Nervensystems (DE)

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