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Life Sciences Advances in Health & Medicine The Effects of Covid-19

From Protein to Medicine

Helmholtz-Zentrum Berlin für Materialien und Energie | Manfred Weiss

Without proteins, life would not be possible. How inhibiting a given protein may lead to a new drug, will be discussed in the lecture.

Proteins are the building blocks of life – whether in humans, animals, plants, bacteria or viruses – every cell needs many different proteins to function. These are huge molecules with a complex three-dimensional structure characterized by cavities, loops and branches. Some proteins cause damage in the organism, so it would be good to block them. This can be achieved by active ingredients, chemical compounds that fit “like a key in a lock” into certain regions of the protein. In the search for active ingredients, it is extremely helpful to know the structure of the protein. To do this, the experts first grow crystals of protein molecules and then screen them with extremely intense X-ray light. At BESSY II, this X-ray light is available at three beamlines for protein crystallography. More than 3,000 structures of important proteins have already been decoded at BESSY II, including proteins that play a role in cancer, malaria or the multiplication of the SARS-CoV-2 virus.

PUBLIC LECTURE AND Q&A VIA LIVESTREAM. PLEASE REGISTER.

This is a digital event. If you would like to attend please book your spot until 2 November here.

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HZB

Manfred Weiss

Helmholtz-Zentrum Berlin für Materialien und Energie

Groupleader Macromlecular Crystallography

Manfred Weiss studied chemistry in Freiburg and also received his doctorate there. After a postdoc in California, USA, and further stations at research institutions in Jena and Hamburg, he joined the Helmholtz-Zentrum Berlin in 2009. There he established special measuring stations for the analysis of protein crystals at the X-ray source BESSY II, which are also in great demand by external measuring guests from all over the world. Since 2016 Manfred Weiss has been head of the Macromolecular Crystallography group at HZB.

More events with Manfred Weiss

Wed | Nov 04, 2020 | 16.00 - 17.30 CET

From Protein to Medicine

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